Mitochondrial Transfer (Three-Parent Children)

Jacob Rees-Mogg Excerpts

Wednesday 12th March 2014 Westminster Hall

[Jacob Rees-Mogg (North East Somerset) (Con)]

I am grateful that the debate has been granted and for the opportunity to serve under your chairmanship, Mr Pritchard. I am delighted that the Under-Secretary of State for Health, my hon. Friend the Member for Battersea (Jane Ellison) will reply, because she is one of the most highly regarded Ministers in Her Majesty’s Government. I would also like to thank my hon. Friend the Member for Congleton (Fiona Bruce) for all her help in preparing for the debate, as well as Dan Boucher, Helen Watt and Luke Gormally.

It is important to begin the discussion by explaining what is at stake with three-parent babies and mitochondria. Mitochondria are the organelles within every cell responsible for the generation of cellular adenosine triphosphate energy. That passes entirely in the maternal line and can carry serious diseases.

There are two means of replacing the mitochondria. Maternal spindle transfer, or MST, takes place before in vitro fertilisation. The spindle, which carries the genes in the nucleus of the egg, is removed from the healthy donor egg and replaced by a spindle taken from the egg of the commissioning mother—that is, the woman at risk of passing on mitochondrial disease. All other parts of the donor egg, including the healthy mitochondria, are left in place. The combined egg is then fertilised by the father’s sperm, and the embryo has three parents: the spindle mother, the egg donor mother and the father. Genetic parenthood is complete in the case of the father but fragmented in the case of the two mothers.

In pronuclear transfer, or PNT, two embryos are created by IVF. One, the embryo of the commissioning women, will have its mother’s affected mitochondrial genes. The other is the healthy embryo of an egg donor. The embryos are combined using a technique somewhat similar to that in the cloning of Dolly the sheep. Interestingly, the licence for the experiment was adapted from the licence originally given for Dolly-style cloning.

[Sir Edward Leigh (Gainsborough) (Con)]

Given that this is obviously an incredibly important matter, akin to cloning, with a child having several parents—I know of no other country in the world that has done this—does my hon. Friend think it should be the subject of a full debate on the Floor of the House?

[Jacob Rees-Mogg]

I certainly think that this matter ought to come to the Floor of the House. I understand from an earlier debate that the Government are committed to full parliamentary scrutiny, but no doubt the Minister will confirm that.

To continue on PNT, at the one-cell stage the donor embryo pronuclei containing the nuclear genes are removed, killing that embryo. The partially gutted donor embryo with its healthy mitochondria is then used to form a new embryo when the pronuclei harvested from the commissioning woman’s embryo are inserted. Harvesting the pronuclei from the commissioning woman’s embryo kills that embryo.

It is important to understand that the techniques are non-therapeutic. They are in no sense a cure for children who are already born, nor do they pretend to be. Rather, the techniques create new people with altered genetic composition—genetically designed individuals who will not inherit mitochondrial disease. Although the mitochondrial DNA is around only 0.1% of a person’s total DNA, a little leaven leavens all the bread, and a different person is thereby created.

The proposed techniques all promote germ-line genetic modification. That is an infinite change that will lead to all the descendants of someone treated in this way being changed, the consequence of which cannot be known.

[Fiona Bruce (Congleton) (Con)]

I thank my hon. Friend for raising this critical subject. Techniques for mitochondrial transfer deliberately create a child who has three genetic ancestors, or, in the case of PNT, four. Is that not extremely concerning, raising as it does serious issues of personal identity for those born through the technique, particularly since Government guidelines propose that such individuals will not be allowed to know the identity of their third or forth parent? Will that not then transfer into future generations, too?

[Jacob Rees-Mogg]

I was going to come on to that. As an aside, the reason we were able to determine that Richard III’s body was his was through the female line, and because we could establish the continuity of the DNA. I do not believe Government promises of secrecy. They promised that to sperm donors historically. Governments cannot be relied upon, because society becomes more open and so demands greater openness. I have no doubt that if the technique is ultimately used the donors will be identified and people with three or potentially four parents will find out.

[Bob Stewart (Beckenham) (Con)]

On that point, the worry that occurs immediately to me as I listen to my hon. Friend is that if someone does not know who the third or fourth person who created them is, through sheer chance they may well find themselves marrying their brother or sister.

[Jacob Rees-Mogg]

That is a risk, and there are others. Already in the United States a different price is charged depending on the educational qualifications of the donor. There are worries about eugenics, a point I was going to come on to.

[Jim Dobbin (Heywood and Middleton) (Lab/Co- op)]

The head of the United States Food and Drug Administration advisory committee on this matter, Evan Snyder, has said that there are not enough clinical data to suggest that mitochondrial transfer is safe. Does the hon. Gentleman agree that the present UK regulator and the UK Government should be cautious in approaching this technique?

[Jacob Rees-Mogg]

I am grateful to the hon. Gentleman for that point. That is at the heart of the issue.

[Robert Flello (Stoke-on-Trent South) (Lab)]

Another issue occurs to me with regard to knowing who the third or, indeed, fourth parent is or was. Let us suppose that, in subsequent generations, further scientific research finds that another fault is being passed down generations. Without knowing whether the third or fourth parent several generations back carried some other gene that has come to the fore only after 150 years, someone would not know whether they were affected. There is a Pandora’s box of problems.

[Jacob Rees-Mogg]

That must be right. It ends up being a multi-generational experiment with the lives of people.

To return to the PNT technique, it is effectively cloning. As I said, it is telling that the licence for the experiment was adapted from the licence given to create Dolly the sheep. Cloning is widely regarded as a dangerous technique. Essentially what is being done is eugenic.

[Glyn Davies (Montgomeryshire) (Con)]

The company that developed Dolly the sheep received funding from an organisation of which I was chairman. I remember visiting it and expressing a concern that it was one step from cloning sheep to cloning humans. I was reassured that no such thing could possibly ever happen, as the human race was far too sensible. This issue challenges that, big time.

[Jacob Rees-Mogg]

As so often, my hon. Friend is right.

The dictionary definition of “eugenic” is:

“Of or bringing about the improvement of the type of offspring produced”.

The 1922 Eugenics Congress called it

“the self direction of human evolution”.

There is grave question mark about eugenics. It frightens almost every sensible person. It is not only people who share my views who think that. In a letter to The Guardian dated 15 March 2013, that fear was made explicit by a number of medical experts. It is interesting that they chose The Guardian, which is not a bastion of right-wing reaction, to make that point. In a country nervous about genetically modified crops we are making the foolhardy move to genetically modified babies.

There are three categories of risks and dangers that have not been fully considered. The first is the category raised by the hon. Member for Stoke-on-Trent South (Robert Flello), namely practical risks relating to the long-term efficacy of the therapy. An article published in Nature in October 2012 said:

“Pioneering work in nonhuman primates is critical for the development, and safety and efficacy evaluations, of new treatments.”

That view has been discounted by the Human Fertilisation and Embryology Authority without any good reason being given. Current research using PNT in macaques has yet to be shown to be successful. Macaque zygotes do not survive the PNT process well, even though their oocytes are less prone to abnormal activation and fertilisation than human ones. If that is the case, surely we should continue with such experiments first, rather than relying on the fact that four monkeys have reached the age of three.

[Robert Flello]

On that point, the research that has been done talks about generations of mice or of monkeys, but that does not address the fact that until there have been three, four, five or 10 generations, we will not know what the long-term effects are.

--- Later in debate ---

[Jacob Rees-Mogg]

I agree with the hon. Gentleman. I also think that mankind is of a different order of magnitude from other animals. I do not view myself merely as a senior ape—nor indeed do I view Opposition Members as merely being senior apes or monkeys. I think much more highly of them than that. [Interruption.] I will gloss over that point. In their article in Nature, Mitalipov et al showed that they had discovered that 52% of human embryos created through MST had chromosomal abnormalities. If there is a high failure rate early on, how can we be certain that there will not be a similar failure rate later, potentially when people are in their 30s or 40s? It is a life-long, generational experiment.

There are also difficulties with the experiments on fruit flies.

An article in Science on 20 September 2013 states:

“MR in fruit flies had little effect on nuclear gene expression in females but changed the expression of roughly 10% of genes in adult males. The mitochondrial haplotypes responsible for these male-specific effects were naturally occurring, putatively healthy variants. Hundreds of mitochondrial-sensitive nuclear genes identified in that study had a core role in male fertility. For example, one of the five combinations in which mitochondrial-nucleus interactions were disrupted by mismatching was completely male-sterile but female-fertile. In other fly studies MR resulted in male-biased modifications to components of ageing”—

that is very important because we do not know what the effects will be as people get older—

“and affected the outcomes of in vivo male fertility. Together, these results suggest that core components of male health depend on fine-tuned coordination between mitochondrial and nuclear gene complexes and thus the HFEA conclusion that ‘there is no evidence for any mismatch between the nucleus and any mtDNA haplogroup at least within a species’ is incomplete and unsubstantiated.”

It has also been discovered from research in mice and invertebrates that deleterious effects on mitochondrial replacement would not be discovered until adulthood, which goes back to the point that we would have to wait decades.

The second category of risk is moral and ethical. I make no bones about the fact that my thinking on this matter is strongly influenced by the Catholic Church concerning the dignity of the human person. Equally, the Minister and the Government should respond to non-theological, non-religious concerns. I will set out briefly the religious concerns.

Thomas Aquinas wrote in his “Summa Theologica” that

“the soul is in the embryo”.

I certainly believe that to be the case. It means that tampering with embryos is tampering with human souls—tampering with what sets us apart from animals. As Benedict XVI in the Instruction “Dignitas Personae” said,

“the body of a human being, from the very first stages of its existence, can never be reduced merely to a group of cells. The embryonic human body develops progressively according to a well defined programme with its proper finality, as is apparent in the birth of every baby.”

That, too, is absolutely correct. No human, whatever their stage of development, is merely a group of cells.

We must be concerned about the unknown consequences of tampering with the genes of an embryo, and for the unreligious there will be mental issues to be faced by those who find out later life that they have three or even four parents. The gravity of the change is such that it should not be made without the most careful thought and properly tested research. [Interruption.]

[Mark Pritchard (in the Chair)]

Order. I am sorry to interrupt the hon. Gentleman. Will whoever has their phone on please turn it off, or put it on silent or vibrate? This is an important debate and it needs to be heard with respect.

[Jacob Rees-Mogg]

Thank you, Mr Prichard. Silence is golden.

The third risk is legal, and I am slightly reluctant to raise it because it concerns the European Union charter of fundamental rights. It is not a document I often quote in support of an argument, but there is a question about its applicability in the United Kingdom. It is not directly applicable in UK law except when it coincides with EU law. There is considerable debate about how far the overlap between UK and EU law goes. Article 3(2) refers to the

“prohibition of eugenic practices, in particular those aiming at the selection of persons”.

I have established that this is eugenics, so it would be in contravention of the Charter of Fundamental Rights. I do not believe that the Government would want to contravene that accidentally.

Essentially, the Government have started too early and are putting the cart before the horse, which makes travel difficult, by consulting on regulatory approval before sufficient research has been done into the safety of the therapy.

[Jim Shannon (Strangford) (DUP)]

I apologise for not being here earlier. The Northern Ireland (Miscellaneous Provisions) Bill was being discussed in the House and I had to be there.

Does the hon. Gentleman accept my concerns on behalf of the people of Northern Ireland who are very worried by what was suggested the other day—that the Department of Health is pressing forward with regulations without full consultation and without the impact being fully known? I hope that the Minister will assure us that that will not happen.

[Jacob Rees-Mogg]

It is essential with such a fundamental change in our understanding of humanity that it is made with the fullest consultation and parliamentary approval. I believe that the Government are sympathetic to that.

[John Glen (Salisbury) (Con)]

Will my hon. Friend explain what evidence he has seen of any preparatory work on the ethical considerations that would be necessary? Is it not the case that many of the regulatory approval processes have commenced, but no proper work has been done with respect to public opinion on the ethics involved?

[Jacob Rees-Mogg]

There is consultation, but it worries me that it has been done before the prior research has been completed, so we cannot be certain about safety.

I am glad that my hon. Friend raises the issue of public opinion, which is unpersuaded. A ComRes poll for Care will be released tomorrow, and I can exclusively reveal some of the results to the House. It found that 34% are opposed and 35% are in support, so there is no strong balance of support but, crucially, 44% agree that as it is currently illegal to grow most genetically modified crops for commercial purposes on the ground of safety, it ought to be illegal to create genetically modified children.

I return to the point that change of even 0.1% leads to genetically modified children. It is not sufficient to say that that is a tiny modification so it does not matter. It is the essence of the line of inheritance that we all have from our mothers through successive generations and centuries.

[Dr Thérèse Coffey (Suffolk Coastal) (Con)]

Does my hon. Friend agree that it is worrying that the assumption is that this will happen and that the consultation is more about how it will happen? Would it not be better for the Minister to say today that the Government will stop the consultation and continue with the research until they are satisfied that the procedure is safe?

[Jacob Rees-Mogg]

My hon. Friend makes a very good point. If the Minister would say that, her standing in North East Somerset would rise even higher, although it is hard to believe that is possible.

The Government’s own consultation—this is crucial—says:

“It is estimated that 1 in 200 children born every year in the UK have some kind of mitochondrial DNA disorder.”

The number of serious disorders is much lower, but one in 200 has some kind of mitochondrial disorder. It is worrying that that is in the consultation because the premise is that 0.5% of the population are born imperfect and that in future only perfect people should be born. Many of us have imperfections, but they make up humanity, and the mixed variety of interest, thoughtfulness and development that is humanity often comes from our faults, as well as our abilities. It is a fundamentally dangerous road to start down because, although the technique cannot at this stage affect eye colour, some clever scientist will eventually work out how to ensure that babies have blue eyes and blonde hair, or whatever people want. Every time something like this happens, we go to the next stage and the argument becomes, “Well, we’ve done this, so it is logical to continue.” When that line has been crossed, the argument against going further is merely a matter of degree; it is not absolute.

[Robert Flello]

I fear that we have already had the push to having perfect babies. Abortion on ground E of disability means that babies with even slight imperfections do not see the light of day.

[Jacob Rees-Mogg]

One aspect of political correctness that I like is calling disabled people “differently able”. People with disabilities have different abilities and skills, and contribute to the benefit of society in a different way from those of us who have the use of all our limbs, and so on.

Although the current aim is small, 10 children every year, who might have been born, will be replaced by 10 different babies. That is not a major problem crying out for an urgent solution, but the solution that is being proposed is a fundamental change in our understanding of our own humanity.