Hormone Pregnancy Tests

Paula Sherriff Excerpts

Tuesday 23rd April 2019 Westminster Hall

[Paula Sherriff (Dewsbury) (Lab)]

It is a pleasure to serve under your chairmanship, Mr Hollobone. Like other hon. Members, I sincerely thank my hon. Friend the Member for Bolton South East (Yasmin Qureshi) for securing this debate. I also thank Marie Lyon, chair of the Association for Children Damaged by Hormone Pregnancy Tests. Without those two strong, brave women and their pursuit of justice, truth and answers, we would probably not be having this debate. I think we can all agree that the personal stories that we have heard today are very powerful indeed, and that these people and their families deserve definitive answers to their questions, especially after so many years.

Although I am pleased that the Government have committed to the ongoing review, I hope that on this occasion all available data will be analysed and all research will be taken into account, so that the review’s conclusion can satisfy those who have campaigned so vociferously for so many years. It is alarming to read the report from experts at Oxford University, led by Carl Heneghan, Professor of Evidence-Based Medicine. The report appears to identify huge gaps in the expert working group’s 2017 study.

To find that huge areas of research were left untouched is nothing short of an insult to the campaigners who have devoted their lives to seeking justice. Some reports suggest that key elements of research were removed on purpose to support the conclusion and mislead Government and Parliament. If so, we as parliamentarians must do our utmost to right those wrongs; I hope that today the Minister will pledge to do just that. Indeed, the Prime Minister herself said in January that she would

“listen very carefully to any recommendations that come out of the review”.—[Official Report, 16 January 2019; Vol. 652, c. 1160.]

The results of animal testing from a 1979 study released by the pharmaceutical manufacturer Schering, now owned by Bayer, found strong links between the drugs and malformations, as well as the death of embryos, and yet the expert working group in 2017 declared that those results provided insufficient evidence. The expert working group examined human studies, and the majority similarly favoured an association between Primodos and deformity, but still the working group felt that the evidence was not strong enough. Was the evidence not properly assessed, or was it simply omitted? Either way, that conclusion has undoubtedly prolonged the agony of those who have lived for 50 years without answers.

There has been much talk about whether meta-analysis should have been used by the expert working group in 2017. When Professor Heneghan carried out a random-effects meta-analysis, the results were opposite to that of the expert working group report and found that there was an association between the drug and the malformations, which was consistent with his own study.

[Sir Edward Davey]

I think I am right in saying that when the raw data that the expert working group had used was rerun by Professor Heneghan, it showed that if the expert working group had done that, it would have reached similar conclusions. That makes the group’s conclusions even more worrying.

[Paula Sherriff]

The right hon. Gentleman makes a very important point, which gives further credibility to the view that the review by the expert working group was completely insufficient.

One thing that I have been utterly appalled about during my research on this subject is the inhumane and patronising way in which women were treated and spoken about during the period that Primodos and other hormone pregnancy tests were available, and subsequently, when a possible link between the drugs, early abortions and birth defects was identified. As the chair and founder of the APPG on women’s health, I am often asked why I feel it necessary to have a group that looks exclusively at women’s health. This is a prime example of the inequality that women have faced over the years when they have sought help on major health issues.

One senior medical officer from the Committee on Safety of Medicines said in 1969:

“It is somewhat difficult to summon up enough enthusiasm to place a high priority on this, when so much other and possibly more important work is pressing.”

In 1968, Dr N.M.B. Dean, of the Royal College of General Practitioners, stated:

“With regard to the rather high incidence of abortions in the Primodos group, I think it must be borne in mind that women going to their doctor for this type of test often hope that they are not pregnant and it is not impossible that these women took other steps to terminate their pregnancies”.

[Emma Reynolds]

Those quotes are breathtakingly horrific. My constituent gave birth in the late 1960s to Steven, who had severe abnormalities thanks to Primodos, and she then went on to conceive two healthy daughters. My constituent wanted to be pregnant, and she wanted a family.

[Paula Sherriff]

My hon. Friend makes an excellent point. Time has not been a healer in this case. We need to understand what has happened and we need to get answers for the affected groups.

The quote from Dr Dean goes on:

“In view of these findings tentative though they are, it would be my own view that, since there is in any event no very sound medical reason (in my opinion) for the use of such hormonal preparations, Primodos should be withdrawn from use.”

To suggest that women going through the pain of dealing with a miscarriage had perhaps taken steps to terminate their pregnancies is nothing short of abhorrent, especially given that Dr Dean went on to suggest that Primodos should be withdrawn from use. That indicates that he did see a link between the drug and the miscarriages. Sadly, the suggestion was completely ignored.

Then there are the poor women whose babies had such severe health issues that they did not survive. Reports from those women include the following:

“1971: the words ‘Monster child’ were written on my medical notes. My baby was born alive. I was not allowed to see her. I was drugged. My baby was taken away. I never saw her again.

1971: Anencephaly. Stillborn 2 weeks early. No funeral allowed. Not allowed to name her. My daughter was put in a coffin with a stranger. Searched for 18 years to find where her remains had been left.

1973: I was 16. Just married and excited about my first baby. Just before my baby was born the doctor said my baby did not have a properly formed head. She had no skull and no brain and would die at birth. I was then heavily sedated and my waters broken. I tried to wake up when my baby was born and begged to see her. They refused as her birth defects were too distressing to see.”

I am sure we all agree that those reports are nothing short of heartbreaking. They are incredibly demeaning for the women involved.

To be put through the most horrendous of situations and made to suffer for all these years without answers has been like a life sentence for some, and those living with complex disabilities face an uncertain future without carers or financial support, should their loved ones die before them. If Primodos and other pregnancy hormone tests were to blame, the answers need to come now, and financial support needs to be given before it really is too late to help those living day to day with the effects of innocently taking a drug after putting their trust in clinicians and drug companies all those years ago.

On listening to stories from those affected and researching the issue, the greatest point that sticks with me is the uncertainty that surrounds all the reports that have been published—the lack of evidence used, the lack of research analysed, the lack of questions answered. I think 50 years is long enough for campaigners to wait. I hope that the Minister will today pledge that she will ensure an end to that wait, and that she will make sure that the findings of the latest review, when published, are acted on thoroughly and comprehensively.