Question to the Department of Health and Social Care:

To ask the Secretary of State for Health and Social Care, if he will publish the outcomes of the (a) SIREN study, (b) Easter6 project and (c) Vivaldi study on the effectiveness of antibodies in providing protection against covid-19.

Analysis of the effectiveness of COVID-19 prior infection and vaccination is conducted regularly within the SIREN study, published in scientific journals and in reports to expert committees. The most recent analysis, published on 16 February 2022 in the New England Journal of Medicine, concluded that infection-acquired immunity or antibody protection boosted with vaccination remained high after one year. This analysis is available at the following link:

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2118691

The Easter 6 project’s latest paper was published in December 2021 in the Lancet, which is available at the following link:

https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(21)00253-1/fulltext

This showed that there was low or no neutralising antibodies in re-infection cases, but that there was a significant boost in titres post reinfection. This project is currently undertaking analysis of its recent data that will be published once complete.

The outcomes of the Vivaldi study are available at the following link:

https://www.gov.uk/government/collections/vivaldi-study-results

The Vivaldi 3 study showed that a COVID-19 booster vaccination markedly increases virus-specific immune responses in residents and staff within care homes. Previous analysis from the Vivaldi study had shown that prior natural infection strongly enhanced subsequent COVID-19 vaccine responses, but that uninfected older people developed suboptimal post-vaccine immunity.