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Written Question
Sexual Dysfunction: Prescription Drugs
Monday 29th April 2024

Asked by: Lord Alton of Liverpool (Crossbench - Life peer)

Question to the Department of Health and Social Care:

To ask His Majesty's Government how many prescriptions for amitriptyline, imipramine and atomoxetine were issued in each year since 2014; how many Yellow Card reports of sexual dysfunction and persistent sexual dysfunction the MHRA has received for each of these drugs in each year since 2014; and whether they will ensure that persistent sexual dysfunction is listed as a side effect in the patient information leaflets for each these drugs.

Answered by Lord Markham - Parliamentary Under-Secretary (Department of Health and Social Care)

Over the next year, the Medicines and Healthcare products Regulatory Agency (MHRA) plans to review the risk of sexual dysfunction and whether these side effects persist for all antidepressants marketed in the United Kingdom. As a result of the review product information will be updated, as necessary, and consideration will be given to whether additional risk minimisation measures are needed.

The following table shows the total number of items in each calendar year between 2014 and 2023, as well as January 2024:

Calendar Year

Amitriptyline Hydrochloride

Atomoxetine Hydrochloride

Imipramine Hydrochloride

2014

11,851,704

118,843

174,731

2015

12,404,537

125,680

167,072

2016

12,943,138

130,731

164,645

2017

13,256,893

134,785

156,555

2018

13,532,567

138,160

150,526

2019

13,975,389

141,907

151,889

2020

14,468,134

146,346

137,284

2021

14,930,177

158,339

123,450

2022

15,226,816

174,894

115,360

2023

15,662,619

178,150

108,197

January 2024

1,370,670

15,334

9,072

Data Source: NHS Business Services Authority Open Data Portal, PCA data

The MHRA has received a total of 38 Yellow Card reports of sexual dysfunction related reactions suspected to be associated with amitriptyline, atomoxetine, and imipramine. Of these, 8 were for amitriptyline, 21 for atomoxetine, and 2 for imipramine.

‘Persistent sexual dysfunction’ does not represent a specific medical condition.

The following table shows a summary of these side effects listed in the product information:

Common (may affect up to 1 in 10 people)

Uncommon (may affect up to 1 in 100 people)

Rare (may affect up to 1 in 1,000 people)

amitriptyline

erectile dysfunction, libido decreased

imipramine

disturbances of libido, impotency or abnormal ejaculation

atomoxetine

libido decreased, ejaculation disorder, erectile dysfunction, male genital pain

Ejaculation failure

Priapism

Select Committee
Maitland Chambers
 RFS0020 - Are the UK’s Russian financial sanctions working?

Written Evidence Apr. 26 2024

Committee: Treasury Committee (Department: HM Treasury)

Found: Under the Terrorist Asset Freezing Act 2010, designations have become very rare, with no new designations

Select Committee
Mr Simon Taft
 RFS0012 - Are the UK’s Russian financial sanctions working?

Written Evidence Apr. 26 2024

Committee: Treasury Committee (Department: HM Treasury)

Found: In the rare event that this did occur, the persons responsible can be prosecuted.

Select Committee
Professor Adam Whitworth
 DYE0045 - Disability employment

Written Evidence Apr. 26 2024

Inquiry: Disability employment
Inquiry Status: Closed
Committee: Work and Pensions Committee (Department: Department for Work and Pensions)

Found: valuable that is to employers as well as disabled people (both in work and looking for work), but how rare

Select Committee
National AIDS Trust
 DYE0011 - Disability employment

Written Evidence Apr. 26 2024

Inquiry: Disability employment
Inquiry Status: Closed
Committee: Work and Pensions Committee (Department: Department for Work and Pensions)

Found: England have an undetectable viral load – meaning that risk of HIV transmission is vanishingly rare

Non-Departmental Publication (Statistics)
The Insolvency Service

Apr. 26 2024

Source Page: Company Insolvency Statistics, March 2024
Document: (ODS)

Found: procedures; however numbers of these are relatively low in comparison. 5 Receivership appointments are now rare

Non-Departmental Publication (Statistics)
The Insolvency Service

Apr. 26 2024

Source Page: Company Insolvency Statistics, March 2024
Document: (Excel)

Found: procedures; however numbers of these are relatively low in comparison.5Receivership appointments are now rare

Deposited Papers

Apr. 26 2024

Source Page: Commitment in letter
Document: Football_Governance_Bill_Impact_Assessment.pdf (PDF)

Found: allows up to 3 players to be contracted outside of the cap.71 In terms of ownership, fan ownership is rare

Deposited Papers

Apr. 26 2024

Source Page: Commitment in letter
Document: Delegated_Powers_Memorandum.pdf (PDF)

Found: wish to delegate discretion to take an alternative approach to determining revenue/remuneratio n in rare

Commons Chamber
Paternity Leave (Bereavement) Bill
3rd reading - Fri 26 Apr 2024
Department for Business and Trade

Mentions:
1: Kevin Hollinrake (Con - Thirsk and Malton) In those tragic, but thankfully rare, circumstances, they need to rely on the compassion of their employer - Speech Link