Brain Tumours: Research and Treatment

Luke Evans Excerpts

Thursday 8th May 2025 Commons Chamber

[Dr Luke Evans (Hinckley and Bosworth) (Con)]

I start with a personal apology to my constituents on this VE Day. While I cannot stand there in person among those marking our victory in remembrance in Hinckley and Bosworth in north-west Leicestershire, I am carrying out the very duty that people gave their lives to protect. The sacrifice of those who fought in world war two ensures that the work of this Parliament and democracy itself endures. Their courage lives in every free debate, every vote cast, and every moment we serve the public good. That should never be forgotten or taken for granted. I am therefore privileged to respond on behalf of His Majesty’s Opposition to such an important topic that resonates with so many—brain tumours.

I pay tribute to the hon. Members for Mitcham and Morden (Dame Siobhain McDonagh) and for Witney (Charlie Maynard) for bringing forward this debate. I was also pleased to hear this important issue raised only yesterday in Prime Minister’s questions by the hon. Member for Forest of Dean (Matt Bishop), talking about his constituent’s remarkable and inspirational story about overcoming glioblastoma. Although the Prime Minister did not respond with details about brain tumours specifically, these are important opportunities to raise and debate this topic while telling the human stories, and I look forward to hearing from the Minister today.

One such story is an example from my own constituency of Hinckley and Bosworth, involving Katherine and Simon Tansey and their daughter Isla. I have told this story in the House in years past, but it is so poignant that I am not shy about telling it again. We can choose to be affected by the world or we can choose to affect the world, and my constituent Isla chose the latter. In August 2017, seven-year-old Isla Tansey woke up unable to walk. After many horrible treatments, surgery and radiotherapy, she was diagnosed with DIPG—diffuse intrinsic pontine glioma—in January 2018. Isla’s mum described the terminal illness as the most traumatic and heartbreaking experience for a family to go through.

Sadly, Isla passed away in July 2018, but not before inspiring thousands around the world with her positivity and creativity through her hobby: painting stones and pebbles. Isla asked others to join her by painting their own stones with any design, but she asked them to include the hashtag #islastones and the words “photo.post.rehide”, and then to send pictures to a dedicated Facebook page for her to see. They were subsequently to leave the stones somewhere hidden so that when they were found, they could spread a little bit of the joy that Isla had given them.

Isla’s mother Katherine hoped that one day a child might find the stones, learn about Isla’s story and become a researcher in childhood cancer. Thousands of people took part, and more than 149 countries were involved. Although Isla could no longer walk, she loved to see where all the stones ended up and where they would travel next. This included the Taj Mahal, New Zealand, Disneyland and America, with one stone reaching Antarctica. Through the stones and the people who made them, hid them and posted their photos, Isla travelled the world.

The hashtag #islastones grew to a community of over 65,000 members from all across the world. In 2019, a year on from Isla’s passing, a world record was set at the Celebration of Smiles event in Hinkley for the largest display of painted stones, with 8,542—all in remembrance of Isla. Off the back of that, Simon and Katherine set up the Islastones Foundation to raise research grants, awareness and smiles to help fight childhood cancer. They were awarded the Points of Light award from the then Prime Minister in 2023.

Why does this matter? We have all heard the statistics in this debate, but these are the real stories behind the cases, and our constituents all rightly ask for real understanding, for listening and for something to change. I am reminded of the quote:

“Your life is a message to the world. Make sure it is inspiring.”

Isla’s message was truly inspiring, and I hope the Government’s message on cancer and brain tumours will be the same.

I turn to the substance of the debate. It is clear today that Members are asking for greater priority to be given to accelerating research into brain tumours and treatments. The motion partly focuses on the £40 million of funding provided by the previous Government for research into brain tumours, and I understand the frustration of MPs from across the House at the speed of allocations to projects since 2018.

At this point, I must pay tribute to the Tessa Jowell Brain Cancer Mission for its work with the NIHR. This collaboration has led to the NIHR issuing funding calls for researchers to evaluate treatments for brain tumours and to expand the network of trials for brain tumours, including the national brain tumour consortium. Looking over the debates, I noticed that the Minister said on Second Reading of the Rare Cancers Bill:

“In the five years since 2018-19, the NIHR has invested £11.3 million directly in brain cancer, with a further £31.5 million to enable brain tumour research in 227 studies involving 8,500 people. The commitment remains in place. I can confirm that there is no upper limit on that funding. We are exploring additional research policy options to encourage more clinical trials in early phase research and the development of medical devices and diagnostics.”—[Official Report, 14 March 2025; Vol. 763, c. 1434.]

That is of course encouraging, but campaigners want to see projects up and running as soon as possible. To that end, would the Minister consider the calls from Brain Tumour Research to create a set of dedicated funding streams for early-career researchers, improved access to clinical trials and better integration of brain tumours in cutting-edge cancer initiatives, especially given the proposed abolition of NHS England?

It is that deep desire to get research moving into potential new treatments that led to the Rare Cancers Bill, proposed by the hon. Member for Edinburgh South West (Dr Arthur). The shadow Secretary of State, my right hon. Friend the Member for Melton and Syston (Edward Argar), was pleased to support the legislation when it was introduced in March. I was glad to note that the Bill received Government support, and it was endorsed by the Brain Tumour Charity, Brain Tumour Research and other patient groups. I welcome the Bill’s intention to encourage industry to concentrate more research on treatments for rare and less common cancers, including brain tumours, particularly through the review of the orphan drug regulations. However, it is vital that there is alignment with the national cancer plan, which is likely to set the direction of cancer policies for the next five to 10 years. Can the Minister confirm whether the key measures in the Bill will be included in the upcoming national cancer plan?

As well as accelerating research into brain tumours, we must take steps to increase participation among those personally affected. One of the aims of the Rare Cancers Bill is to get more patients into clinical trials for rare cancers, including brain tumours. It is sobering that the Brain Tumour Charity’s survey found that only 12% of respondents have participated in a clinical trial. We also know from the Institute of Cancer Research that brain tumour clinical trials have the lowest recruitment of any cancer type. This is why the last Government asked Lord O’Shaughnessy to review the barriers to commercial clinical trials in the aftermath of the covid pandemic. I know that the Government have stated that they are committed to implementing the recommendations of the O’Shaughnessy review, but can the Minister provide further details on what progress has been made to date?

On a side note—but a related one—at a recent VE Day celebration in Donisthorpe I met a constituent who raised with me the issue of the acquired brain injury strategy. That cross-party initiative has been championed by the hon. Member for Rhondda and Ogmore (Chris Bryant), who is now a Labour Minister. Somewhat fortuitously, I was able to tell my constituent that I was taking part in a debate on brain tumours today. She and the likes of Headway and the Child Brain Injury Trust are keen to ensure that they are able to support people through the changes that the Government are pushing through on personal independence payments and disability support, so would the Minister consider reviewing or updating the acquired brain injury strategy in the light of these changes?

Finally, I want to end on a positive note. The discussions between the MHRA and Northwest Biotherapeutics are providing hope that people living with new or recurrent glioblastoma may have access to a new treatment, DCVax-L, which could make a real difference in prolonging their survival from this terrible disease. It is important that we build on these developments, and take steps to reduce barriers to research in brain tumours and access to new treatments as they develop. After all, as one brain tumour survivor said:

“Hope is the anchor that kept me steady through the storm of my diagnosis”.

I hope that this very debate will bring hope to those suffering and their families, and will demonstrate that the Government are listening and working for better outcomes.