Question to the Department for Science, Innovation & Technology:

To ask His Majesty's Government, regarding Replacing animals in science: A strategy to support the development, validation and uptake of alternative methods, published on 11 November, whether they will consider including monoclonal antibodies as part of their priority areas for targeted replacement of animal tests; and how the target to replace the use of animal-derived polyclonal-type antibodies by 2030 will be enforced.

The Government’s strategy to support replacing animals in science commits to, from 2026, publish biennially a list of alternative-methods research and development priorities, to coalesce UK scientists and incentivise partnerships between research organisations, CROs and industry. These priority areas will be developed collaboratively between Government, academia, industry, and other partners. Monoclonal antibody testing will be considered as a potential area.

Enforcement of the target to replace animal-derived polyclonal antibodies is provided for by existing law which states animals cannot be used where a validated alternative exists. Therefore licences would not be granted once alternative methods have been validated and agreed.