Question to the Department of Health and Social Care:

To ask His Majesty's Government, further to the Written Answer by Baroness Merron on 4 March (HL14721) indicating a substantial underspend in the Innovative Medicines Fund, what steps they are taking to expand managed access pathways for innovative medicines, including disease-modifying treatments for Alzheimer’s disease such as Lecanemab and Donanemab.

NHS England cannot comment on the proportion of the Innovative Medicines Fund’s budget that has been spent on medicines made available through managed access agreements. Due to the low numbers of patients who receive these highly specialised treatments, publishing this information risks confidentiality of pricing.

The National Institute for Health and Care Excellence (NICE) is able to recommend any medicine, including for the treatment of Alzheimer’s disease, for a period of managed access through the Innovative Medicines Fund where it concludes that it is plausibly cost effective and the collection of real-world evidence may resolve clinical uncertainty. NICE concluded in its draft guidance on lecanemab and donanemab that neither treatment was suitable for a period of managed access but has not yet published its final guidance. There are no current plans to expand the circumstances in which NICE is able recommend medicines for managed access.