Question to the Department of Health and Social Care:

To ask Her Majesty's Government, further to the Written Answer by Lord Kamall on 2 November (HL3362), what were the affected genes in the mitochondrial genome and the associated mutations in each of the 24 patients licensed as eligible for mitochondrial replacement treatment; and on what dates each corresponding application was approved by the Human Fertilisation and Embryology Authority.

The following table shows the gene affected and the mutation in the 26 patients licensed as eligible for mitochondrial donation treatment, the date each application was made and then approved by the Human Fertilisation and Embryology Authority (HFEA) Statutory Approvals Committee.

HFEA Application reference Gene affected by mutation Mutation Date received Date approved by the HFEA Statutory Approvals Committee

M0001 MT-TK Details omitted to protect patient identity 28 June 2017 31 August 2017

M0002 MT-TK Details omitted to protect patient identity 4 September 2017 26 October 2017

M0007 MT-ND1 m.3460 G>A 13 March 2018 24 May 2018

M0003 MT-TL1 Details omitted to protect patient identity 25 September 2017 26 July 2018

M0005 MT-TL1 m.3243 A>G 5 December 2017 26 July 2018

M0008 MT-TL1 m.3243 A>G 15 March 2018 26 July 2018

M0004 MT-TK Details omitted to protect patient identity 4 December 2017 30 August 2018

M0006 MT-TS1 Details omitted to protect patient identity 9 January 2018 30 August 2018

M0009 MT-TI m.4300 A>G 28 June 2018 27 September 2018

M0010 MT-TI m.4300 A>G 11 July 2018 27 September 2018

M0013 MT-ND4 m.11778 G>A 14 July 2018 25 October 2018

M0012 MT-ND1 m.3460 G>A 13 July 2018 25 October 2018

M0014 MT-ND4 m.11778 G>A 23 November 2018 31 January 2019

M0015 MT-ND4 m.11778 G>A 23 November 2018 31 January 2019

M0011 MT-ND4 m.11778 G>A 12 July 2018 29 August 2019

M0016 MT-TK m.8344 A>G 5 July 2019 26 September 2019

M0017 MT-ND4 m.11778 G>A 22 August 2019 31 October 2019

M0018 MT-TL1 Details omitted to protect patient identity 10 December 2019 26 March 2020

M0019 MT-TL1 Details omitted to protect patient identity 10 December 2019 26 March 2020

M0020 MT-TL1 Details omitted to protect patient identity 30 March 2020 25 June 2020

M0021 MT-ND1 Details omitted to protect patient identity 30 March 2020 25 June 2020

M0022 MT-ND1 Details omitted to protect patient identity 26 June 2020 24 September 2020

M0024 MT-ND4 Details omitted to protect patient identity 9 December 2020 29 July 2021

M0025 MT-ND4 Details omitted to protect patient identity 9 December 2020 29 July 2021

M0026 MT-ND4 Details omitted to protect patient identity 7 June 2021 4 October 2021

M0027 MT-ND1 Details omitted to protect patient identity 7 June 2021 4 October 2021

Source: HFEA